CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation
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چکیده
منابع مشابه
Design and development of CAR-T cells for cancer therapy
Introduction: Today, treatment with CAR-T cells is accepted as an effective treatment for blood malignancies. CAR-T cells are autologous T cells that are engineered by gene transfer techniques to express a chimeric antigen receptor (CAR). Despite the promising results and the approval of six CAR-T cell products; these products have not yet been approved for solid tumors. In addition, the high c...
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During the past 70 years, cancer therapy has undergone extensive growth from pharmacotherapy toward targeted therapy, poised upon the considerations of efficacy and safety of clinically applied drugs [1]. The strategy behind this growth was to optimize the structures of the drugs, from synthesized chemical entities to biologics, to enhance the specificity between drugs and disease targets for b...
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In recent years, the chimeric antigen receptor modified T cells (Chimeric antigen receptor T cells, CAR-T) immunotherapy has developed rapidly, which has been considered the most promising therapy. Efforts to enhance the efficacy of CAR-based anti-tumor therapy have been made, such as the improvement of structures of CAR-T cells, including the development of extracellular antigen recognition re...
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Immunotherapy with genetically engineered T-cells that express the chimeric antigen receptor (CAR) has raised hopes for the treatment of pediatric malignancies. Although CAR T-cell development is on a fast-moving pace and evolution, the context of exploring novel targetable antigens has been neglected. In this review study, we analyze the prominent hematologic antigens targeted by engineered T-...
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CAR (Chimeric Antigen receptor)-T cell therapy is a novel type of therapy that uses engineered T cells with an antibody single-chain variable fragment (ScFv) extracellular domain that binds tumor-associated antigens[...].
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ژورنال
عنوان ژورنال: Journal for ImmunoTherapy of Cancer
سال: 2018
ISSN: 2051-1426
DOI: 10.1186/s40425-018-0347-5